Description

4-Chloro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzonitrile is a high-purity, synthetically valuable boronic ester derivative, serving as a critical building block in modern cross-coupling reactions. Its core value lies in enabling the precise construction of complex aromatic and heteroaromatic systems, which are fundamental to advanced material and pharmaceutical research. This compound is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries who require reliable, high-quality intermediates for Suzuki-Miyaura coupling.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing substituted benzonitrile or biphenyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific chlorinated aromatic structures.
• Material Science: Serves as a monomer or building block for creating organic semiconductors, liquid crystals, and polymers with tailored electronic properties.
• Chemical Research: A versatile reagent in academic and industrial laboratories for methodology development in palladium-catalyzed cross-coupling reactions.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts.
• Fine Chemical Production: Integral to the multi-step synthesis of complex dyes, pigments, and other high-value specialty chemicals.

Basic Information

Product Name	4-Chloro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzonitrile
CAS No.	863868-19-3
Molecular Formula	C13H15BClNO2
Molecular Weight	263.53 g/mol
Synonyms	2-Chloro-4-cyanophenylboronic acid pinacol ester; 4-Chloro-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile; (4-Chloro-2-cyanophenyl)boronic acid pinacol ester; 2-Cyano-5-chlorophenylboronic acid pinacol ester; Pinacol (4-chloro-2-cyanophenyl)boronate; 863868-19-3; 4-Chloro-2-(pinacolatoboryl)benzonitrile
EINECS	Contact for details

Quality Control

Our 4-Chloro-2-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-Yl)-Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material meets the stringent requirements for research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent hydrolysis of the boronic ester group. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.