Description

(2R,3R,4R)-3-(Benzyloxy)-2-(Benzyloxymethyl)-4-Fluoro-5-Methoxy-Tetrahydrofuran CAS NO 863642-44-8 is a high-purity, chiral fluorinated tetrahydrofuran derivative, serving as a critical advanced intermediate in modern synthetic chemistry. Its precise stereochemistry and functional groups make it an invaluable building block for constructing complex bioactive molecules. This compound is primarily sought after by pharmaceutical R&D and fine chemical synthesis teams for the development of nucleoside analogs, antiviral agents, and other high-value specialty chemicals.

Application

• Pharmaceutical Intermediate: Key chiral synthon in the research and development of novel nucleoside-based antiviral and anticancer therapeutics.
• Antiviral Pro-drug Synthesis: Used in the synthetic pathway for fluorinated nucleoside analogs, which are pivotal in treating viral infections.
• Organic Synthesis Building Block: Employed in asymmetric synthesis and medicinal chemistry for introducing fluorinated tetrahydrofuran motifs into target molecules.
• Glycoscience Research: Acts as a modified sugar analog for studying enzyme mechanisms and developing glycosidase inhibitors.
• Process Chemistry & Scale-up: Serves as a critical intermediate in the pilot and commercial-scale manufacturing of active pharmaceutical ingredients (APIs).
• Agrochemical Research: Potential intermediate for creating novel fluorinated compounds with biological activity for crop protection.

Basic Information

Item	Details
Product Name	(2R,3R,4R)-3-(Benzyloxy)-2-(Benzyloxymethyl)-4-Fluoro-5-Methoxy-Tetrahydrofuran
CAS No.	863642-44-8
Molecular Formula	C20H23FO4
Molecular Weight	346.39 g/mol
Synonyms	(2R,3R,4R)-3-(Benzyloxy)-2-(Benzyloxymethyl)-4-Fluoro-5-Methoxy-Tetrahydrofuran; 4-Fluoro-3-O-benzyl-2-O-benzyloxymethyl-5-O-methyl-D-ribofuranose (protected form); Fluorinated Ribofuranose Derivative; 2,3-Di-O-benzyl-4-fluoro-5-O-methyl-D-ribofuranose; CAS 863642-44-8; Fluorinated Tetrahydrofuran Intermediate; Benzyl-protected Fluororibofuranose
EINECS	Contact for details

Quality Control

We supply this high-value intermediate under strict quality protocols to ensure batch-to-batch consistency for sensitive synthetic applications. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with stringent control over stereochemical purity and key impurities. Certificates of Analysis (COA) are provided with each batch, detailing results for assay, chiral purity, identity (IR, NMR), and residual solvents. We adhere to cGMP principles for manufacturing and can support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive (store away from light). For long-term storage under inert atmosphere (nitrogen or argon) is recommended to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.