Description

Cebranopadol Hemicitrate CAS NO 863513-92-2 is a high-purity, non-narcotic analgesic compound belonging to the novel class of NOP and opioid receptor agonists. This compound is of significant interest for advanced pharmaceutical research and development due to its unique dual mechanism of action, which offers a promising profile for managing moderate to severe chronic pain. It is primarily utilized by research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the discovery and formulation of next-generation analgesic therapies.

Application

• Pharmaceutical Reference Standard: Serves as a certified standard for analytical method development, validation, and quality control in drug manufacturing.
• Preclinical & Clinical Research: Used in in vitro and in vivo studies to investigate pharmacokinetics, pharmacodynamics, and efficacy profiles for pain management.
• Active Pharmaceutical Ingredient (API) Development: A key intermediate in the R&D pipeline for formulating new analgesic drug products.
• Mechanistic Studies: Employed in neurological and pharmacological research to study the interaction and signaling of NOP/opioid receptor systems.
• Impurity Profiling: Used to identify and quantify related substances during API synthesis and purification processes.

Basic Information

Product Name	Cebranopadol Hemicitrate
CAS No.	863513-92-2
Molecular Formula	C₂₇H₃₀N₂O₅ • C₆H₈O₇
Molecular Weight	634.65 g/mol
Synonyms	TRV-734; Cebranopadol citrate; (1r,3r)-N-[(3r,4r)-1-(Cyclopropylmethyl)-3-(hydroxymethyl)-4-piperidinyl]-3-fluoro-4,5-dihydro-1h-benzo[g]indazole-5-carboxamide hemicitrate; 1-[(3R,4R)-1-(Cyclopropylmethyl)-3-(hydroxymethyl)piperidin-4-yl]-3-fluoro-4,9-dihydro-1H-benzo[6,7]cyclohepta[1,2-c]pyrazole-5-carboxamide hemicitrate
EINECS	Contact for details

Quality Control

Our Cebranopadol Hemicitrate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, detailing all critical quality attributes to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept in a desiccated environment to prevent moisture absorption. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.