Description

7-Hydroxy Alosetron is a key pharmaceutical intermediate and metabolite of the drug alosetron. This compound matters for its critical role in the research, development, and quality control of therapeutic agents targeting irritable bowel syndrome (IBS). It is primarily needed by pharmaceutical manufacturers, analytical laboratories, and research institutions engaged in drug metabolism studies, impurity profiling, and the synthesis of advanced active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of Alosetron hydrochloride and related therapeutic compounds.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Metabolite Studies: Essential for pharmacokinetic and pharmacodynamic research to understand the drug's metabolic pathway and bioavailability.
• Impurity Profiling: Serves as a specified impurity standard to ensure the purity and safety of the final drug substance according to ICH guidelines.
• Biochemical Research: Utilized in in-vitro studies to investigate the mechanism of action and receptor binding affinity of 5-HT3 antagonists.

Basic Information

Product Name	7-Hydroxy Alosetron
CAS No.	863485-44-3
Molecular Formula	C17H18N4O
Molecular Weight	294.35 g/mol
Synonyms	7-Hydroxy Alosetron; 2,3,4,5-Tetrahydro-5-methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-1H-pyrido[4,3-b]indol-1-one, 7-Hydroxy Derivative; Alosetron Metabolite; 7-OH-Alosetron; Lotronex Metabolite; GR 68755C Metabolite; (5-Methyl-2-[(5-methyl-1H-imidazol-4-yl)methyl]-2,3,4,5-tetrahydro-1H-pyrido[4,3-b]indol-1-one, 7-Hydroxy-
EINECS	Contact for details

Quality Control

Our 7-Hydroxy Alosetron is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets high-purity standards suitable for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.