Description

6-Trifluoromethyl-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester is a high-value fluorinated heterocyclic building block essential for advanced organic synthesis. This compound is critical for researchers and manufacturers developing novel active pharmaceutical ingredients (APIs) and agrochemicals, where the introduction of a trifluoromethyl group can dramatically alter biological activity and metabolic stability. It is primarily utilized in medicinal chemistry, agrochemical research, and material science for creating complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for kinase inhibitors and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Serves as a precursor for novel herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science Research: Used in the development of organic electronic materials, such as organic semiconductors and non-linear optical (NLO) materials.
• Chemical Biology: Employed as a probe or labeling agent in biochemical research due to its distinct spectroscopic signature.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses serving the pharmaceutical and agrochemical industries.

Basic Information

Product Name	6-Trifluoromethyl-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester
CAS No.	863118-41-6
Molecular Formula	C11H7F3O2S
Molecular Weight	260.23 g/mol
Synonyms	Methyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate; 6-(Trifluoromethyl)-1-benzothiophene-2-carboxylic acid methyl ester; 2-Methoxycarbonyl-6-trifluoromethylbenzo[b]thiophene; Benzo[b]thiophene-2-carboxylic acid, 6-(trifluoromethyl)-, methyl ester; 863118-41-6; Methyl 6-trifluoromethyl-1-benzothiophene-2-carboxylate
EINECS	Contact for details

Quality Control

Our production of 6-Trifluoromethyl-Benzo[B]Thiophene-2-Carboxylic Acid Methyl Ester adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality management system is designed to support cGMP compliance for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible organic solvents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.