Description

3-(Chloromethyl)-1H-Indole-1-Carboxylic Acid 1,1-Dimethylethyl Ester is a high-purity, protected indole derivative that serves as a critical synthetic intermediate in advanced organic synthesis. Its value lies in providing a reactive chloromethyl handle and a tert-butyloxycarbonyl (Boc) protected nitrogen, enabling precise and sequential functionalization for complex molecule construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and plant growth regulators that leverage the indole scaffold.
• Peptidomimetics & PROTACs: Serves as a versatile precursor for constructing indole-containing peptide analogs and Proteolysis Targeting Chimeras (PROTACs) in medicinal chemistry.
• Material Science Research: Employed in the development of organic semiconductors, ligands for catalysis, and advanced polymeric materials.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis services targeting niche and high-value chemical entities.

Basic Information

Product Name	3-(Chloromethyl)-1H-Indole-1-Carboxylic Acid 1,1-Dimethylethyl Ester
CAS No.	862704-32-3
Molecular Formula	C15H18ClNO2
Molecular Weight	279.76 g/mol
Synonyms	3-(Chloromethyl)-1H-indole-1-carboxylic acid tert-butyl ester; 1-Boc-3-(chloromethyl)indole; tert-Butyl 3-(chloromethyl)-1H-indole-1-carboxylate; 3-Chloromethyl-1H-indole-1-carboxylic acid tert-butyl ester; 1-(tert-Butoxycarbonyl)-3-(chloromethyl)indole; Boc-3-(chloromethyl)indole; 862704-32-3; 3-(Chloromethyl)indole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our production of 3-(Chloromethyl)-1H-Indole-1-Carboxylic Acid 1,1-Dimethylethyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for your critical synthesis workflows. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support cGMP-compliant manufacturing for advanced pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.