Description

1H-Indole-3-Carboxylic Acid, 1-[(2-Chloro-6-Fluorophenyl)Methyl]-,Methyl Ester is a high-purity, fluorinated indole derivative designed for advanced chemical synthesis. This compound serves as a critical pharmaceutical intermediate and a versatile building block in medicinal chemistry research. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in central nervous system (CNS) and oncology therapeutic areas.
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization due to its indole core and halogen substitutions.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced pesticides and herbicides, leveraging its unique halogenated aromatic structure.
• Chemical Biology Probes: Employed in the synthesis of molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A starting material for custom synthesis projects requiring complex, multi-step organic transformations.

Basic Information

Product Name	1H-Indole-3-Carboxylic Acid, 1-[(2-Chloro-6-Fluorophenyl)Methyl]-,Methyl Ester
CAS No.	862654-25-9
Molecular Formula	C17H13ClFNO2
Molecular Weight	317.74 g/mol
Synonyms	Methyl 1-[(2-Chloro-6-fluorophenyl)methyl]-1H-indole-3-carboxylate; 1-[(2-Chloro-6-fluorobenzyl)]-1H-indole-3-carboxylic acid methyl ester; 1-(2-Chloro-6-fluorobenzyl)indole-3-carboxylic acid methyl ester; 862654-25-9; 1H-Indole-3-carboxylic acid, 1-[(2-chloro-6-fluorophenyl)methyl]-, methyl ester; Methyl 1-(2-chloro-6-fluorobenzyl)-1H-indole-3-carboxylate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications. We support development and commercial projects with GMP-grade material upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed and away from direct light sources to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Any single unknown impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.