Description

1-(Mesitylsulfonyl)-1H-Indole-3-Carbaldehyde is a versatile and high-value sulfonylated indole derivative, serving as a critical advanced intermediate in modern organic synthesis. Its core value lies in its dual functional groups—the aldehyde and the mesitylsulfonyl-protected indole nitrogen—which enable precise and complex molecular construction. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of novel heterocyclic compounds and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of complex indole-based drug candidates, including kinase inhibitors and receptor modulators.
• Agrochemical Research: Used in the development of new herbicides and fungicides that leverage the indole scaffold for biological activity.
• Material Science: Serves as a precursor for functional organic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Academic & R&D: A valuable reagent in methodological organic chemistry for studying new sulfonylation reactions and heterocyclic formation.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke chemical synthesis and scale-up projects.
• Chemical Biology: Useful as a probe or linker in bioconjugation chemistry due to its reactive aldehyde group.

Basic Information

Product Name	1-(Mesitylsulfonyl)-1H-Indole-3-Carbaldehyde
CAS No.	862583-35-5
Molecular Formula	C19H17NO3S
Molecular Weight	339.41 g/mol
Synonyms	1-[(2,4,6-Trimethylphenyl)sulfonyl]-1H-indole-3-carboxaldehyde; 1H-Indole-3-carboxaldehyde, 1-[(2,4,6-trimethylphenyl)sulfonyl]-; 1-Mesitylsulfonylindole-3-carbaldehyde; 3-Formyl-1-mesitylsulfonylindole; 1-Ms-indole-3-carbaldehyde (common abbreviation); Indole-3-carboxaldehyde, N-mesitylsulfonyl derivative; N-Mesitylsulfonylindole-3-carboxaldehyde
EINECS	Contact for details

Quality Control

Every batch of 1-(Mesitylsulfonyl)-1H-Indole-3-Carbaldehyde is manufactured under strict quality management systems. Our products undergo rigorous quality testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency, meeting the stringent requirements of research and development. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its sensitivity to oxidation, it is recommended to store the material under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.