Description

Bicyclo[2.2.2]Octane-1-Carboxylic Acid, 4-Amino-, 1,1-Dimethylethyl Ester is a high-value, sterically hindered bicyclic building block prized for its rigid three-dimensional structure and protected amine functionality. This compound is essential for advanced organic synthesis, particularly in the development of novel pharmaceuticals and sophisticated materials where precise spatial control is critical. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) with complex, conformationally restricted scaffolds, potentially for neurological or antiviral targets.
• Agrochemical Synthesis: Used in the research and development of novel herbicides or fungicides where the bicyclo[2.2.2]octane core can impart metabolic stability and unique bioactivity.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands or organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced polymers or metal-organic frameworks (MOFs) to introduce rigidity and specific functional groups.
• Peptidomimetics and PROTACs: The protected amino acid derivative is valuable for constructing peptide analogs and proteolysis-targeting chimeras (PROTACs) in drug discovery.
• Academic and Industrial R&D: A versatile reagent for methodological studies and exploring new chemical space in medicinal and synthetic chemistry.

Basic Information

Product Name	Bicyclo[2.2.2]Octane-1-Carboxylic Acid, 4-Amino-, 1,1-Dimethylethyl Ester
CAS No.	862501-92-6
Molecular Formula	C14H23NO2
Molecular Weight	237.34 g/mol
Synonyms	4-Aminobicyclo[2.2.2]octane-1-carboxylic acid tert-butyl ester; tert-Butyl 4-aminobicyclo[2.2.2]octane-1-carboxylate; 4-Amino-BCO-t-butyl ester; 1-Boc-4-aminobicyclo[2.2.2]octane-1-carboxylic acid (tautomer); Bicyclo[2.2.2]octan-1-amine, 4-(1,1-dimethylethoxy)carbonyl]-; 4-Amino-1-Boc-bicyclo[2.2.2]octane-1-carboxylic acid; 1-N-Boc-4-aminobicyclo[2.2.2]octane-1-carboxylic acid; BCO-NH2-Boc ester
EINECS	Contact for details

Quality Control

Every batch of Bicyclo[2.2.2]Octane-1-Carboxylic Acid, 4-Amino-, 1,1-Dimethylethyl Ester is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and development applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request and can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.