Description

Herkinorin is a potent and selective synthetic agonist for the kappa opioid receptor (KOR). This compound matters as a critical research tool for neuroscientists and pharmacologists studying pain pathways, addiction, and mood disorders. It is needed by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) focused on developing novel analgesics and neuropsychiatric therapeutics.

Application

• Neuroscience Research: Used as a selective pharmacological probe to investigate the role of the kappa opioid receptor in the central nervous system.
• Analgesic Development: Serves as a reference compound and lead structure in the discovery of new, non-addictive pain relief medications.
• Psychiatric Disorder Studies: Applied in preclinical research to model and understand the neurobiology of depression, anxiety, and substance abuse disorders.
• Signal Transduction Analysis: Utilized in in vitro assays (e.g., cAMP inhibition, β-arrestin recruitment) to characterize receptor activation and downstream effects.
• Metabolic Pathway Investigation: Employed in studies to understand the metabolism and pharmacokinetics of synthetic opioids.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Herkinorin
CAS No.	862073-77-6
Molecular Formula	C₂₄H₂₅NO₄
Molecular Weight	391.46 g/mol
Synonyms	Herkinorin; Salvinorin B ethoxymethyl ether; 2-[(1S,2S,4aS,6aR,6bS,7R,9S,10aS,10bR)-7-(Ethoxymethoxy)-1,2,6a,6b,9,10a-hexamethyl-9,10-dihydro-4aH-benzo[a]fluorene-4a-carbonyl]-5,6-dimethoxyphenol; 2-[(4aR,6aR,7R,9S,10aR,10bR)-9-(Ethoxymethoxy)-2,2,6a,10b-tetramethyl-8-oxo-3,4,6,6a,7,8,9,10,10a,10b-decahydro-1H-benzo[a]fluoren-7-yl]-5,6-dimethoxyphenol
EINECS	Contact for details

Quality Control

Our Herkinorin is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity confirmation, NMR and MS for structural identity, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting purity, identity, and all relevant specifications is provided with every shipment to ensure traceability and compliance with research-grade material standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep the container sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.