Description

Dodecyl-D25-Phosphocholine CAS NO 861924-55-2 is a deuterated analog of dodecylphosphocholine, a critical non-ionic detergent used in membrane protein research. This compound is essential for solubilizing and stabilizing integral membrane proteins in their native state for structural and functional studies. It is primarily utilized by research institutions, pharmaceutical companies, and biotech firms engaged in advanced biochemistry, structural biology, and drug discovery.

Application

• Membrane Protein Solubilization: Extraction and stabilization of integral membrane proteins from lipid bilayers for biochemical analysis.
• Structural Biology: Preparation of protein samples for techniques like X-ray crystallography, cryo-electron microscopy (cryo-EM), and NMR spectroscopy.
• Biophysical Studies: Use in fluorescence spectroscopy, isothermal titration calorimetry (ITC), and surface plasmon resonance (SPR) to study protein-ligand interactions.
• Drug Discovery Platforms: Enabling high-throughput screening (HTS) assays for membrane-bound drug targets such as G protein-coupled receptors (GPCRs).
• Lipid Nanodisc Formation: Aiding in the creation of lipid nanodiscs that mimic native cell membranes for studying membrane protein function.
• Deuterium Labeling for NMR: The deuterated (D25) alkyl chain provides signal reduction in proton NMR, simplifying spectra for complex protein analysis.

Basic Information

Product Name	Dodecyl-D25-Phosphocholine
CAS No.	861924-55-2
Molecular Formula	C17D25NO4P
Molecular Weight	Contact for details
Synonyms	Dodecylphosphocholine-d25; DPC-d25; 1-Dodecylphosphocholine-d25; Deuterated Dodecylphosphocholine; Laurylphosphocholine-d25; Fos-Choline-12-d25; (Dodecyl-D25)-2-(trimethylammonio)ethyl phosphate; 2-[[(Dodecyl-D25)oxy]-hydroxyphosphoryl]oxy]-N,N,N-trimethylethanaminium
EINECS	Contact for details

Quality Control

Our Dodecyl-D25-Phosphocholine is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including NMR and HPLC, to ensure high chemical purity and isotopic enrichment. Certificates of Analysis (COA) detailing purity, deuterium content, and critical specifications are provided with every shipment to support your research compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. This material is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98%
Deuterium Enrichment	≥ 98 atom % D
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.