Description

Nicotinic Acid-D3 (Major) is a high-purity, isotopically labeled analog of nicotinic acid (vitamin B3), specifically designed for use as an internal standard in quantitative analytical methods. This deuterated compound is essential for ensuring accuracy and reliability in mass spectrometry-based analyses by correcting for variations in sample preparation and instrument response. It is a critical tool for researchers and quality control laboratories in the pharmaceutical, clinical research, and nutritional science industries who require precise quantification of nicotinic acid and its metabolites.

Application

• Quantitative Mass Spectrometry: Serves as a stable isotope-labeled internal standard for the accurate LC-MS/MS quantification of nicotinic acid in complex biological matrices like plasma, serum, and urine.
• Pharmacokinetic and Metabolic Studies: Enables precise tracking of drug absorption, distribution, metabolism, and excretion (ADME) for nicotinic acid and related pharmaceutical compounds.
• Clinical Diagnostics: Used in the development and validation of high-precision assays for monitoring vitamin B3 status and related metabolic disorders.
• Nutritional Research: Facilitates the accurate measurement of nicotinic acid content and bioavailability in fortified foods, dietary supplements, and nutritional studies.
• Biomarker Analysis: Critical for the reliable quantification of nicotinic acid and its metabolites as potential biomarkers in disease research.
• Method Development & Validation: Provides a reference standard for developing, optimizing, and validating new analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).

Basic Information

Product Name	Nicotinic Acid-D3 (Major)
CAS No.	861405-75-6
Molecular Formula	C6D3H2NO2
Molecular Weight	126.13 g/mol
Synonyms	Pyridine-3-carboxylic acid-D3; 3-Carboxypyridine-D3; Vitamin B3-D3; Niacin-D3; Deuterated Nicotinic Acid; [2,4,6-D3]-Nicotinic Acid; 3-Pyridinecarboxylic-2,4,6-d3 acid
EINECS	Contact for details

Quality Control

Every batch of Nicotinic Acid-D3 (Major) is manufactured and analyzed under strict quality management systems. Our products undergo rigorous quality testing, including NMR and mass spectrometry, to confirm isotopic enrichment, chemical purity, and structural identity, ensuring compliance with the high standards required for analytical research. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Chemical Purity (NMR)	Conforms
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.