Description

5-(4-Chloro-Phenyl)-4-Ethyl-Thiophene-2-Carboxylic Acid is a high-purity, synthetically versatile heterocyclic building block of significant commercial importance. This compound is a critical intermediate in the research and development of advanced pharmaceutical and agrochemical products. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Research: Serves as a core structural component in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene scaffold.
• Material Science Precursor: Used in the synthesis of organic semiconductors, conductive polymers, and non-linear optical (NLO) materials due to its electron-rich thiophene core.
• Ligand and Catalyst Development: Employed in organometallic chemistry to create novel ligands for catalysis and metal-organic frameworks (MOFs).
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects and scale-up processes.

Basic Information

Product Name	5-(4-Chloro-Phenyl)-4-Ethyl-Thiophene-2-Carboxylic Acid
CAS No.	861226-90-6
Molecular Formula	C13H11ClO2S
Molecular Weight	266.74 g/mol
Synonyms	4-Ethyl-5-(4-chlorophenyl)thiophene-2-carboxylic acid; 5-(4-Chlorophenyl)-4-ethyl-2-thiophenecarboxylic acid; 2-Thiophenecarboxylic acid, 5-(4-chlorophenyl)-4-ethyl-; 861226-90-6; 4-Ethyl-5-(p-chlorophenyl)thiophene-2-carboxylic acid; 5-(p-Chlorophenyl)-4-ethylthiophene-2-carboxylic acid
EINECS	Contact for details

Quality Control

Our production of 5-(4-Chloro-Phenyl)-4-Ethyl-Thiophene-2-Carboxylic Acid adheres to stringent in-process controls and final release testing to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay, identity, and impurity profiles. Our quality system is designed to meet the rigorous standards required for pharmaceutical and agrochemical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.