Description

Methyl 3-Iodo-1-(Phenylsulfonyl)-1H-Indole-2-Carboxylate is a high-value, multi-functional heterocyclic building block designed for advanced synthetic chemistry. This compound is essential for researchers and process chemists developing novel pharmaceuticals and agrochemicals, particularly those targeting kinase inhibition or other biologically relevant pathways. Its core value lies in enabling the rapid construction of complex indole-based molecular architectures, which are prevalent in active pharmaceutical ingredients (APIs). Key industries that require this material include pharmaceutical R&D, contract research and manufacturing organizations (CROs/CMOs), and agrochemical discovery labs.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex indole derivatives for drug discovery programs, especially in oncology and CNS therapeutic areas.
• Agrochemical Research: Used as a key scaffold for developing novel crop protection agents and herbicides with new modes of action.
• Chemical Biology Probe Synthesis: Employed in creating molecular probes to study enzyme function and protein-protein interactions within biological systems.
• Material Science: Serves as a monomer or functional unit in the development of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine substituent makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce diverse functional groups.
• Academic & Institutional Research: A valuable reagent for methodology development and exploring new synthetic routes in organic chemistry laboratories.

Basic Information

Product Name	Methyl 3-Iodo-1-(Phenylsulfonyl)-1H-Indole-2-Carboxylate
CAS No.	860611-94-5
Molecular Formula	C16H12INO4S
Molecular Weight	441.24 g/mol
Synonyms	Methyl 3-iodo-1-(phenylsulfonyl)-1H-indole-2-carboxylate; 1H-Indole-2-carboxylic acid, 3-iodo-1-(phenylsulfonyl)-, methyl ester; 3-Iodo-1-(phenylsulfonyl)indole-2-carboxylic acid methyl ester; Methyl 3-iodo-1-tosylindole-2-carboxylate (common name); 860611-94-5; 1-(Phenylsulfonyl)-3-iodo-1H-indole-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 3-Iodo-1-(Phenylsulfonyl)-1H-Indole-2-Carboxylate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality commitment aligns with the standards expected by pharmaceutical and advanced research customers, ensuring reliability for your most demanding synthesis projects.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is light-sensitive (store away from light). Keep the container tightly sealed to protect from moisture and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.