Description

4-Hydroxy-3-Methoxy-D3-Cinnamic Acid is a high-purity, deuterium-labeled derivative of ferulic acid, a naturally occurring phenolic compound. This stable isotope-labeled analog is essential for advanced analytical and research applications where precise quantification and metabolic pathway tracing are required. It is primarily utilized by researchers and manufacturers in the pharmaceutical, nutraceutical, and analytical chemistry sectors for use as an internal standard in mass spectrometry and in the development of deuterated drug candidates.

Application

• Internal Standard for LC-MS/MS Analysis: Critical for the accurate quantification of ferulic acid and related metabolites in complex biological matrices like plasma, serum, and plant extracts.
• Deuterated Reference Material: Serves as a certified reference standard in method development and validation for quality control laboratories.
• Pharmaceutical Research: Used in drug metabolism and pharmacokinetics (DMPK) studies to trace the absorption, distribution, metabolism, and excretion (ADME) of phenolic compounds.
• Isotope Dilution Mass Spectrometry (IDMS): Enables highly precise and accurate measurements, improving data reliability in clinical and forensic toxicology.
• Synthesis of Deuterated Drug Candidates: Acts as a key building block for creating more metabolically stable pharmaceutical compounds.
• Nutraceutical & Cosmetic Research: Employed in stability and bioavailability studies of antioxidant formulations containing ferulic acid.

Basic Information

Item	Details
Product Name	4-Hydroxy-3-Methoxy-D3-Cinnamic Acid
CAS No.	860605-59-0
Molecular Formula	C10H7D3O4
Molecular Weight	197.21 g/mol
Synonyms	Ferulic Acid-d3; 3-(4-Hydroxy-3-methoxyphenyl)-2-propenoic-2,3,3-d3 Acid; (E)-3-(4-Hydroxy-3-methoxyphenyl)acrylic-2,3,3-d3 Acid; 4-Hydroxy-3-methoxycinnamic Acid-d3; Deuterated Ferulic Acid; Coniferic Acid-d3; 3-Methoxy-4-hydroxycinnamic Acid-d3
EINECS	Contact for details

Quality Control

Our 4-Hydroxy-3-Methoxy-D3-Cinnamic Acid is manufactured under strict quality systems to ensure exceptional isotopic purity and chemical integrity. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results from advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. We guarantee batch-to-batch consistency and traceability to support your critical research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (NMR/MS)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.