Description

tert-Butyl 6-Methoxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a high-purity, protected heterocyclic building block of significant value in advanced organic synthesis. This compound serves as a critical intermediate for the construction of complex molecules, particularly in pharmaceutical research and development. It is essential for medicinal chemists and process development scientists working on central nervous system (CNS) agents, alkaloid derivatives, and other bioactive isoquinoline-based scaffolds.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the development of novel drug candidates, particularly those targeting neurological disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization for isoquinoline-containing compounds.
• Alkaloid Synthesis: Serves as a protected core structure for the semi-synthesis or total synthesis of complex natural products and their analogs.
• Process Chemistry: Employed in route scouting and scale-up for the production of active pharmaceutical ingredients (APIs).
• Chemical Biology: Utilized as a molecular scaffold or probe in biochemical and pharmacological studies.
• Academic & Institutional R&D: A valuable reagent for universities and research institutes exploring new synthetic methodologies and heterocyclic chemistry.

Basic Information

Product Name	tert-Butyl 6-Methoxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	860436-57-3
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-6-methoxy-, 1,1-dimethylethyl ester; 6-Methoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; Boc-6-Methoxy-1,2,3,4-tetrahydroisoquinoline; N-Boc-6-methoxy-1,2,3,4-tetrahydroisoquinoline; tert-Butyl 6-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 6-Methoxy-N-Boc-1,2,3,4-tetrahydroisoquinoline; 860436-57-3
EINECS	Contact for details

Quality Control

Our tert-Butyl 6-Methoxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with the standards required for pharmaceutical R&D and cGMP starting material applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.