Description

tert-Butyl 5-Methoxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is a protected heterocyclic amine derivative, serving as a versatile and high-purity synthetic intermediate. This compound is crucial for pharmaceutical research and development, enabling the controlled synthesis of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for constructing isoquinoline-based scaffolds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) targeting neurological and cardiovascular disorders.
• Organic Synthesis Reagent: Used in multi-step synthesis for the construction of complex nitrogen-containing heterocycles.
• Medicinal Chemistry Research: Employed in the discovery and optimization of new drug candidates, particularly those based on the tetrahydroisoquinoline core.
• Process Chemistry Development: Serves as a standardized intermediate for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological pathways.

Basic Information

Product Name	tert-Butyl 5-Methoxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate
CAS No.	860436-56-2
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	2(1H)-Isoquinolinecarboxylic acid, 3,4-dihydro-5-methoxy-, 1,1-dimethylethyl ester; 5-Methoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; Boc-5-MeO-THIQ; tert-Butyl 5-methoxy-1,2,3,4-tetrahydroisoquinoline-2-carboxylate; 5-Methoxy-2-Boc-1,2,3,4-tetrahydroisoquinoline; 860436-56-2; 5-MeO-THIQ-Boc
EINECS	Contact for details

Quality Control

Our tert-Butyl 5-Methoxy-3,4-Dihydroisoquinoline-2(1H)-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistency. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.