Description

5-[(Acetylamino)Methyl]Thiophene-2-Sulfonyl Chloride CAS NO 859491-07-9 is a high-purity, reactive sulfonyl chloride derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role in introducing the sulfonamide functional group, enabling the creation of molecules with targeted biological activity. It is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of sulfonamide-based drug candidates, including potential kinase inhibitors and antimicrobial agents.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides by incorporating the thiophene-sulfonamide scaffold.
• Chemical Biology & Proteomics: Serves as a reactive handle for activity-based protein profiling (ABPP) and the development of chemical probes.
• Material Science: Potential monomer or cross-linking agent in the development of specialty polymers and functional materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke intermediates under cGMP or research-grade conditions.

Basic Information

Product Name	5-[(Acetylamino)Methyl]Thiophene-2-Sulfonyl Chloride
CAS No.	859491-07-9
Molecular Formula	C8H8ClNO3S2
Molecular Weight	265.73 g/mol
Synonyms	N-[(5-Chlorosulfonyl-2-thienyl)methyl]acetamide; 2-Thiophenesulfonyl chloride, 5-[(acetylamino)methyl]-; 5-(Acetamidomethyl)thiophene-2-sulfonyl chloride; 5-(Acetylamino-methyl)-thiophene-2-sulfonyl chloride; Acetamide, N-[(5-chlorosulfonyl-2-thienyl)methyl]-; 859491-07-9
EINECS	Contact for details

Quality Control

Our 5-[(Acetylamino)Methyl]Thiophene-2-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment. We support development and commercial projects with material suitable for research use or produced under current Good Manufacturing Practice (cGMP) guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or after opening to prevent decomposition. Keep away from strong acids, bases, and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.