Description

Methyl 5-Bromo-2-((tert-Butoxycarbonyl)Amino)Thiophene-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a protected amino group and a brominated thiophene core. This compound is critical for enabling efficient and selective synthetic routes in medicinal chemistry, particularly for the development of novel active pharmaceutical ingredients (APIs). It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those targeting kinase inhibition and other biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical entities.
• Agrochemical Synthesis: Serves as a precursor for developing new herbicides and fungicides with thiophene-based structures.
• Material Science: Potential monomer or precursor for the synthesis of specialty polymers and organic electronic materials.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services.
• Academic Research: Used in university and institutional labs for methodological development and heterocyclic chemistry studies.

Basic Information

Product Name	Methyl 5-Bromo-2-((tert-Butoxycarbonyl)Amino)Thiophene-3-Carboxylate
CAS No.	859204-25-4
Molecular Formula	C11H14BrNO4S
Molecular Weight	336.20 g/mol
Synonyms	Methyl 5-bromo-2-[(tert-butoxycarbonyl)amino]thiophene-3-carboxylate; 5-Bromo-2-((tert-butoxycarbonyl)amino)thiophene-3-carboxylic acid methyl ester; 2-((tert-Butoxycarbonyl)amino)-5-bromothiophene-3-carboxylic acid methyl ester; Boc-5-Bromo-2-aminothiophene-3-carboxylic acid methyl ester; Methyl 5-bromo-2-(Boc-amino)thiophene-3-carboxylate; tert-Butyl (5-bromo-3-(methoxycarbonyl)thiophen-2-yl)carbamate; 859204-25-4; Boc-5-Br-2-Amino-Thiophene-3-COOMe
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-2-((tert-Butoxycarbonyl)Amino)Thiophene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support compliance with cGMP, ICH Q7, and REACH standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to minimize exposure to moisture. For long-term storage, consider storage under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.