Description

Ethyl 6-Bromobenzo[D]Isothiazole-3-Carboxylate is a high-value brominated heterocyclic building block essential for advanced organic synthesis. This compound is specifically designed to serve as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and infectious diseases.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the benzoisothiazole core.
• Material Science: Serves as a building block for creating organic semiconductors, liquid crystals, and photoactive polymers due to its conjugated system and bromine handle for further functionalization.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) and molecular tags for studying enzyme function and protein interactions.
• Cross-Coupling Reactions: The bromine atom at the 6-position makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to create diverse biaryl and alkynyl derivatives.

Basic Information

Item	Detail
Product Name	Ethyl 6-Bromobenzo[D]Isothiazole-3-Carboxylate
CAS No.	858671-74-6
Molecular Formula	C10H8BrNO2S
Molecular Weight	286.14 g/mol
Synonyms	6-Bromobenzo[d]isothiazole-3-carboxylic acid ethyl ester; Ethyl 6-bromobenzo[d]isothiazole-3-carboxylate; 6-Bromo-1,2-benzisothiazole-3-carboxylic acid ethyl ester; 6-Bromobenzoisothiazole-3-carboxylic acid ethyl ester; 858671-74-6; Ethyl 6-bromo-1,2-benzisothiazole-3-carboxylate; 3-Ethoxycarbonyl-6-bromobenzo[d]isothiazole
EINECS	Contact for details

Quality Control

Our Ethyl 6-Bromobenzo[D]Isothiazole-3-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent chemical identity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.