Description

6-(Difluoromethoxy)-1H-Indazole-3-Carboxylic Acid is a high-purity, functionalized indazole derivative of significant interest in advanced organic synthesis. This compound serves as a critical pharmaceutical intermediate for the development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring precise molecular modification. It is primarily utilized by research institutions, contract research organizations (CROs), and pharmaceutical manufacturers engaged in drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates targeting various disease pathways.
• Medicinal Chemistry Research: Used for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Agrochemical Development: Serves as a precursor for creating novel compounds with potential herbicidal or pesticidal activity.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and biological mechanisms.
• Custom Synthesis: Employed by fine chemical suppliers for the contract manufacturing of complex, high-value specialty chemicals.
• Academic Research: Used in university laboratories for methodological development in heterocyclic and fluorine chemistry.

Basic Information

Product Name	6-(Difluoromethoxy)-1H-Indazole-3-Carboxylic Acid
CAS No.	858661-80-0
Molecular Formula	C9H6F2N2O3
Molecular Weight	228.15 g/mol
Synonyms	6-(Difluoromethoxy)-1H-indazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 6-(difluoromethoxy)-; 6-(Difluoromethoxy)-1H-indazol-3-carboxylic acid; 6-Difluoromethoxy-1H-indazole-3-carboxylic acid; 858661-80-0; 6-(Difluoromethoxy)indazole-3-carboxylic acid; 3-Carboxy-6-(difluoromethoxy)indazole
EINECS	Contact for details

Quality Control

Our 6-(Difluoromethoxy)-1H-Indazole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.