Description

5-Difluoromethoxyindazole-3-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate characterized by its unique indazole core functionalized with difluoromethoxy and carboxylic acid groups. This compound is of significant value for medicinal chemistry research and development, serving as a critical building block for synthesizing novel active pharmaceutical ingredients (APIs). It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of new therapeutic agents, particularly in areas requiring sophisticated fluorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially kinase inhibitors and other targeted therapies.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Biochemical Tool Compound: Employed in the development of chemical probes for investigating biological pathways and target validation.
• Fine Chemical Synthesis: Serves as a specialized building block for constructing complex, fluorinated organic molecules in custom synthesis projects.

Basic Information

Product Name	5-Difluoromethoxyindazole-3-Carboxylic Acid
CAS No.	858661-78-6
Molecular Formula	C9H6F2N2O3
Molecular Weight	228.15 g/mol
Synonyms	5-(Difluoromethoxy)-1H-indazole-3-carboxylic acid; 1H-Indazole-3-carboxylic acid, 5-(difluoromethoxy)-; 5-(Difluoromethoxy)indazole-3-carboxylic acid; DFMICA; 858661-78-6
EINECS	Contact for details

Quality Control

Our production of 5-Difluoromethoxyindazole-3-Carboxylic Acid adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.