Description

5-Fluoro-3-Iodo-1H-Indazole is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in its unique halogenated indazole structure, which serves as a versatile scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of targeted kinase inhibitors and other small-molecule drug candidates, leveraging the indazole core's bioisosteric properties.
• Agrochemical Research: Used in the development of new herbicides and fungicides, where the halogenated indazole moiety can contribute to biological activity.
• Material Science: Serves as a building block for organic electronic materials, such as OLEDs and semiconductors, due to its electron-deficient aromatic system.
• Chemical Biology Probe Development: Employed in the design and synthesis of molecular probes for studying enzyme function and cellular pathways.
• Cross-Coupling Reactions: The iodine atom provides an excellent handle for versatile palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to introduce complex substituents.
• Library Synthesis for Drug Discovery: A valuable input for high-throughput and combinatorial chemistry to generate diverse compound libraries for screening.

Basic Information

Product Name	5-Fluoro-3-Iodo-1H-Indazole
CAS No.	858629-06-8
Molecular Formula	C7H4FIN2
Molecular Weight	261.92 g/mol
Synonyms	3-Iodo-5-fluoro-1H-indazole; 5-Fluoro-3-iodoindazole; 1H-Indazole, 5-fluoro-3-iodo-; 858629-06-8; 5-Fluoro-3-iodo-1H-indazole; 3-Iodo-5-fluoroindazole; 5-Fluoro-3-iodo-1H-indazole (CAS 858629-06-8)
EINECS	Contact for details

Quality Control

Our 5-Fluoro-3-Iodo-1H-Indazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC/IR)	Conforms to reference standard
Purity (HPLC)	≥ 97.0%
Assay	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.