Description

Spiro[3H-Indole-3,4-Piperidine]-1-Carboxylic Acid, 1,2-Dihydro-6-Methoxy-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate with a complex spirocyclic indole-piperidine structure. This compound is critical for research and development in medicinal chemistry, particularly for its role as a key building block in the synthesis of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing central nervous system (CNS) and other bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs due to its complex, privileged spirocyclic scaffold.
• API Development: A key precursor in the multi-step synthesis of potential Active Pharmaceutical Ingredients (APIs) with spirocyclic architectures.
• Chemical Biology Probes: Employed in the development of molecular probes to study biological pathways and protein interactions.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for the pharmaceutical industry.
• Academic Research: Utilized in university and institutional labs for exploratory synthetic chemistry and pharmacological studies.

Basic Information

Item	Details
Product Name	Spiro[3H-Indole-3,4-Piperidine]-1-Carboxylic Acid, 1,2-Dihydro-6-Methoxy-, 1,1-Dimethylethyl Ester
CAS No.	858351-41-4
Molecular Formula	C19H26N2O3
Molecular Weight	330.43 g/mol
Synonyms	tert-Butyl 1,2-dihydro-6-methoxyspiro[3H-indole-3,4'-piperidine]-1'-carboxylate; 1'-Boc-6-methoxyspiro[indoline-3,4'-piperidine]; 6-Methoxy-1,2-dihydrospiro[3H-indole-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; 1,1-Dimethylethyl 1,2-dihydro-6-methoxy-spiro[3H-indole-3,4-piperidine]-1-carboxylate; 6-Methoxyspiro[indoline-3,4'-piperidine]-1'-carboxylic acid tert-butyl ester; Spiro[indoline-3,4'-piperidine]-1'-carboxylic acid, 1,2-dihydro-6-methoxy-, 1,1-dimethylethyl ester; 858351-41-4
EINECS	Contact for details

Quality Control

Our Spiro[3H-Indole-3,4-Piperidine]-1-Carboxylic Acid, 1,2-Dihydro-6-Methoxy-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific client requirements for research or cGMP-grade material.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.