Description

tert-Butyl 1H-Spiro[Isoquinoline-4,4'-Piperidine]-2(3H)-Carboxylate is a high-purity, advanced pharmaceutical intermediate featuring a complex spirocyclic and heterocyclic molecular architecture. This compound is of significant commercial value as a critical building block in modern medicinal chemistry, enabling the synthesis of novel therapeutic agents. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of central nervous system (CNS) drugs and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, particularly those targeting neurological receptors.
• Medicinal Chemistry Research: Used as a versatile scaffold for constructing libraries of novel compounds in high-throughput screening and structure-activity relationship (SAR) studies.
• API Development: Serves as a crucial building block in the research and development stages of new Active Pharmaceutical Ingredients (APIs).
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for use in custom synthesis and scale-up projects.
• Academic Research: Utilized in university and institutional labs for investigating new synthetic pathways and pharmacological mechanisms.

Basic Information

Product Name	tert-Butyl 1H-Spiro[Isoquinoline-4,4'-Piperidine]-2(3H)-Carboxylate
CAS No.	857898-70-5
Molecular Formula	C18H24N2O2
Molecular Weight	300.40 g/mol
Synonyms	1,1-Dimethylethyl 1'H-spiro[4H-3,1-benzoxazine-4,4'-piperidine]-2(3H)-carboxylate; tert-Butyl 1'H-spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylate; 2-tert-Butoxycarbonyl-1,2,3,4-tetrahydrospiro[isoquinoline-4,4'-piperidine]; Spiro[isoquinoline-4,4'-piperidine]-2(3H)-carboxylic acid, 1,1-dimethylethyl ester; BOC-Spiro[isoquinoline-4,4'-piperidine]; 857898-70-5
EINECS	Contact for details

Quality Control

Our production of tert-Butyl 1H-Spiro[Isoquinoline-4,4'-Piperidine]-2(3H)-Carboxylate adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. The material is characterized and released using advanced analytical techniques including HPLC, GC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.