Description

m-Peg3-S-Acetyl is a high-purity, functionalized polyethylene glycol (PEG) derivative featuring a terminal thioacetate group. This compound serves as a critical heterobifunctional linker and building block in advanced bioconjugation and pharmaceutical development. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences sectors for creating stable, cleavable linkages in drug delivery systems, antibody-drug conjugates (ADCs), and protein modification.

Application

• Bioconjugation Reagent: Used for site-specific modification of proteins, peptides, and antibodies via thiol-reactive chemistry.
• ADC (Antibody-Drug Conjugate) Development: Acts as a key linker component, connecting cytotoxic payloads to monoclonal antibodies with a cleavable disulfide bond.
• PEGylation Agent: Enables the controlled PEGylation of therapeutic molecules to enhance solubility, stability, and circulation half-life.
• Crosslinking and Surface Modification: Employed in material science for functionalizing surfaces, nanoparticles, and hydrogels.
• Prodrug Synthesis: Facilitates the design of prodrugs where the active agent is released upon specific biological triggers.
• Polymer Chemistry Building Block: Serves as a monomer or functional initiator in the synthesis of advanced polymeric materials.

Basic Information

Product Name	m-Peg3-S-Acetyl
CAS No.	857284-78-7
Molecular Formula	C11H22O5S
Molecular Weight	266.35 g/mol
Synonyms	1-Acetylthio-3,6,9-trioxaundecan-11-ol; Acetyl-PEG3-thiol; mPEG3-S-Acetyl; 11-Hydroxy-3,6,9-trioxaundecyl thioacetate; 2-[2-[2-(2-Hydroxyethoxy)ethoxy]ethoxy]ethyl thioacetate; HS-PEG3-OH (S-acetyl protected); Thioacetic acid S-(2-[2-(2-hydroxyethoxy)ethoxy]ethyl) ester; m-PEG3-Thioacetate
EINECS	Contact for details

Quality Control

Our m-Peg3-S-Acetyl is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.