Description

(R)-Methyl 2-(((Benzyloxy)Carbonyl)Amino)-3-(7-Methyl-1H-Indazol-5-Yl)Propanoate is a high-purity, non-natural amino acid derivative featuring a chiral center and a 7-methylindazole moiety, making it a critical chiral building block for advanced pharmaceutical synthesis. Its precise stereochemistry and functional groups are essential for constructing complex molecules with specific biological activity. This compound is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutics, particularly in the areas of oncology and targeted drug discovery. CAS No. 855778-40-4.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted cancer therapies.
• Peptidomimetic Research: Used to incorporate non-natural amino acid structures into peptide chains to enhance stability, bioavailability, and receptor binding affinity.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged compounds for studying biological pathways and target engagement.
• Process Chemistry & Scale-up: Provides a defined starting material for optimizing synthetic routes from laboratory to pilot and commercial production scales.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and process development for client projects.
• Academic Research: Utilized in university and institutional labs for methodological development in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	(R)-Methyl 2-(((Benzyloxy)Carbonyl)Amino)-3-(7-Methyl-1H-Indazol-5-Yl)Propanoate
CAS No.	855778-40-4
Molecular Formula	C21H23N3O4
Molecular Weight	381.43 g/mol
Synonyms	(R)-Methyl 2-(((Benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoate; (R)-Methyl 2-(N-Cbz-amino)-3-(7-methyl-1H-indazol-5-yl)propanoate; (R)-Cbz-7-Methyl-DL-tryptophan methyl ester analog; (R)-2-((((Benzyloxy)carbonyl)amino)-3-(7-methyl-1H-indazol-5-yl)propanoic acid methyl ester; (R)-N-Carbobenzoxy-3-(7-methyl-1H-indazol-5-yl)-alanine methyl ester; 855778-40-4; Z-7-Methyl-D-Trp-OMe (indazole analog)
EINECS	Contact for details

Quality Control

Every batch of (R)-Methyl 2-(((Benzyloxy)Carbonyl)Amino)-3-(7-Methyl-1H-Indazol-5-Yl)Propanoate is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality systems are designed to meet the stringent requirements of pharmaceutical R&D and process development. A comprehensive Certificate of Analysis (COA) detailing chiral purity, assay, and impurity profiles by HPLC is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.