Description

n-2-Hydroxyethyl-n-(Methyl-D3)-p-Toluenesulfonamide is a deuterated derivative of a tosylamide compound, featuring a selectively deuterated methyl group. This deuteration is critical for enhancing metabolic stability and reducing the rate of hydrogen-deuterium exchange in pharmacokinetic and metabolic studies. It serves as a valuable synthetic intermediate and reference standard for researchers in pharmaceutical development and analytical chemistry, particularly for applications requiring isotopic labeling.

Application

• Pharmaceutical Intermediate: Used in the synthesis of deuterated drug candidates to improve metabolic profiles and study ADME (Absorption, Distribution, Metabolism, and Excretion) properties.
• Metabolic Research: Acts as an internal standard in LC-MS (Liquid Chromatography-Mass Spectrometry) and GC-MS (Gas Chromatography-Mass Spectrometry) for the accurate quantification of non-deuterated analogs in biological matrices.
• Isotope Labeling Studies: Employed in mechanistic studies and reaction pathway elucidation where deuterium tracing is required.
• Chemical Biology Probes: Utilized in the development of labeled probes for investigating protein-ligand interactions and enzyme mechanisms.
• Reference Material: Serves as a high-purity certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	n-2-Hydroxyethyl-n-(Methyl-D3)-p-Toluenesulfonamide
CAS No.	854634-39-2
Molecular Formula	C10H12D3NO3S
Molecular Weight	230.30 g/mol
Synonyms	N-(2-Hydroxyethyl)-N-[(methyl-d3)]-4-methylbenzenesulfonamide; N-Methyl-d3-N-(2-hydroxyethyl)tosylamide; Deuterated N-Methyl-N-(2-hydroxyethyl)toluenesulfonamide; 4-Methyl-N-(2-hydroxyethyl)-N-(trideuteriomethyl)benzenesulfonamide; (Methyl-d3)-N-(2-hydroxyethyl)-p-toluenesulfonamide; N-(2-Hydroxyethyl)-N-(methyl-d3)-p-toluenesulfonamide; N-Ethanol-N-(methyl-d3)-p-toluenesulfonamide
EINECS	Contact for details

Quality Control

Our n-2-Hydroxyethyl-n-(Methyl-D3)-p-Toluenesulfonamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical and isotopic purity, NMR for structural confirmation, and MS for identity verification. Certificates of Analysis (COA) detailing batch-specific results for assay, deuterium enrichment, and impurity profiles are provided to ensure traceability and compliance with research and development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive); ensure the container is sealed under an inert atmosphere after each use to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (Deuterium Enrichment)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.