Description

1H-Indazole-1-Carboxylic Acid, 3-Iodo-5-(Phenylmethoxy)-, 1,1-Dimethylethyl Ester is a high-purity, advanced pharmaceutical intermediate characterized by its specific indazole core and halogenated, protected structure. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of complex molecules with targeted biological activity. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new active pharmaceutical ingredients (APIs), particularly for oncology and central nervous system (CNS) therapeutic areas.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of novel drug candidates, especially those targeting specific enzyme pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop compounds with improved efficacy and pharmacokinetic profiles.
• API Development: Serves as a protected, functionalized scaffold for constructing complex heterocyclic structures found in investigational new drugs.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological processes and target validation due to its modifiable iodine moiety.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects on behalf of pharmaceutical clients.

Basic Information

Product Name	1H-Indazole-1-Carboxylic Acid, 3-Iodo-5-(Phenylmethoxy)-, 1,1-Dimethylethyl Ester
CAS No.	854633-04-8
Molecular Formula	C19H19IN2O3
Molecular Weight	450.28 g/mol
Synonyms	tert-Butyl 3-iodo-5-(benzyloxy)-1H-indazole-1-carboxylate; 3-Iodo-5-(phenylmethoxy)-1H-indazole-1-carboxylic acid 1,1-dimethylethyl ester; 1-(tert-Butoxycarbonyl)-3-iodo-5-(benzyloxy)indazole; Boc-3-Iodo-5-BnO-indazole; 854633-04-8; 3-Iodo-5-benzyloxy-1H-indazole-1-carboxylic acid tert-butyl ester
EINECS	Contact for details

Quality Control

Our 1H-Indazole-1-Carboxylic Acid, 3-Iodo-5-(Phenylmethoxy)-, 1,1-Dimethylethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. This material is light-sensitive and should be stored away from direct light exposure.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.