Description

3β-tert-Butyldimethylsilyloxy-17-Methyl-5α-Androstane-17β-Ol-D5 is a high-purity, deuterated steroid derivative used as a critical intermediate in advanced pharmaceutical research and development. This compound is valued for its role in the synthesis of novel therapeutic agents and as a stable isotope-labeled internal standard for precise analytical quantification. It is primarily utilized by research institutions and pharmaceutical companies engaged in metabolic studies, drug discovery, and the development of high-performance liquid chromatography (HPLC) and mass spectrometry (MS) methods.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel steroid-based therapeutics and active pharmaceutical ingredients (APIs).
• Stable Isotope-Labeled Standard: Serves as an internal standard (D5-labeled) for accurate quantification in bioanalytical methods using LC-MS/MS and GC-MS.
• Metabolic Research: Used in tracer studies to investigate steroid metabolism, pharmacokinetics, and biochemical pathways.
• Reference Standard: Provides a certified reference material for quality control and method validation in analytical laboratories.
• Drug Discovery & Development: Facilitates structure-activity relationship (SAR) studies and the creation of deuterated drug candidates for improved metabolic stability.
• Academic Research: Employed in university and institutional labs for fundamental studies in organic chemistry and endocrinology.

Basic Information

Product Name	3β-tert-Butyldimethylsilyloxy-17-Methyl-5α-Androstane-17β-Ol-D5
CAS No.	853904-64-0
Molecular Formula	C26H47D5O2Si
Molecular Weight	427.8 g/mol (approx.)
Synonyms	17-Methyl-5α-androstane-3β,17β-diol 3-tert-butyldimethylsilyl ether-d5; 3β-[(tert-Butyldimethylsilyl)oxy]-17-methyl-5α-androstan-17β-ol-d5; Deuterated TBDMS-androstanediol derivative; 3β-TBDMS-O-17-methyl-5α-androstane-17β-ol-d5; Androstane-d5 TBDMS ether; 17-Methylandrostanediol-d5 3-TBDMS ether; (3β,5α,17β)-17-Methyl-3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]androstan-17-ol-d5
EINECS	Contact for details

Quality Control

Our 3β-tert-Butyldimethylsilyloxy-17-Methyl-5α-Androstane-17β-Ol-D5 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including NMR, HPLC, and MS, to ensure identity, purity, and isotopic enrichment meet the highest standards for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profile is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (MS)	≥ 98 atom % D
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.