Description

(R)-3-Phenyl-2-(1-Pyrrolidinyl)-1-Propanol CAS NO 853180-09-3 is a chiral amino alcohol building block of significant importance in asymmetric synthesis. Its value lies in its utility as a key intermediate for constructing complex pharmaceutical molecules, particularly those requiring high enantiomeric purity. This compound is essential for research and development chemists and process scale-up teams in the pharmaceutical and fine chemical industries.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in central nervous system (CNS) and cardiovascular drug candidates.
• Asymmetric Catalyst Ligand Precursor: Used to develop and synthesize novel chiral ligands for transition metal catalysis, enabling enantioselective transformations.
• Building Block for Alkaloid Synthesis: Serves as a core structural unit in the preparation of complex natural products and alkaloid analogs for medicinal chemistry research.
• Chiral Resolution Agent: Can be employed in the resolution of racemic mixtures of acids or other compounds due to its basic nitrogen and chiral center.
• Process Chemistry & Scale-Up: Suitable for use in kilogram-scale laboratory development and pilot plant production of target molecules.
• Academic & Industrial R&D: A valuable tool for method development and exploring new synthetic routes in academic and corporate research settings.

Basic Information

Product Name	(R)-3-Phenyl-2-(1-Pyrrolidinyl)-1-Propanol
CAS No.	853180-09-3
Molecular Formula	C₁₃H₁₉NO
Molecular Weight	205.30 g/mol
Synonyms	(R)-3-Phenyl-2-(pyrrolidin-1-yl)propan-1-ol; (R)-1-Phenyl-3-(pyrrolidin-1-yl)propan-2-ol; (R)-2-(1-Pyrrolidinyl)-3-phenyl-1-propanol; (R)-Norephedrine pyrrolidine derivative; (R)-Phenylpropanolamine pyrrolidine analog; (R)-β-Hydroxy-β-phenyl-N-pyrrolidinylethylamine; (R)-1-Phenyl-2-pyrrolidin-1-yl-1-ethanol
EINECS	Contact for details

Quality Control

Our (R)-3-Phenyl-2-(1-Pyrrolidinyl)-1-Propanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity (enantiomeric excess) determination by HPLC, to ensure it meets the high standards required for advanced synthetic applications. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.