Description

Tributyl[4-(4-Fluorophenyl)-6-Isopropyl-2-[(2-n-Methyl-n-Methyl Sulfonyl)Amino]Pyrimidine-5-Yl-Methyl]Phosphine Bromine is a sophisticated organophosphorus compound with a complex pyrimidine core, designed for advanced chemical synthesis and pharmaceutical research. This molecule is valued for its unique structure, which combines a phosphine ligand with a halogenated heterocycle, making it a critical intermediate in the development of novel active pharmaceutical ingredients (APIs) and specialty catalysts. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly those targeting kinase inhibition or other enzyme-related pathways.
• Catalyst Ligand Precursor: Serves as a precursor for generating specialized phosphine-based ligands used in transition metal catalysis, such as cross-coupling reactions (e.g., Suzuki, Heck).
• Agrochemical Research: Used in the development of new-generation herbicides or fungicides where the fluorophenyl-pyrimidine motif is biologically active.
• Chemical Biology Probe Development: Employed to create molecular probes for studying biological processes and protein interactions due to its modifiable functional groups.
• Material Science Research: Potential use in the synthesis of organic electronic materials or metal-organic frameworks (MOFs) where its structure can influence material properties.

Basic Information

Product Name	Tributyl[4-(4-Fluorophenyl)-6-Isopropyl-2-[(2-n-Methyl-n-Methyl Sulfonyl)Amino]Pyrimidine-5-Yl-Methyl]Phosphine Bromine
CAS No.	853066-73-6
Molecular Formula	C₃₂H₄₆BrFN₃O₂PS
Molecular Weight	666.66 g/mol (Contact for details)
Synonyms	4-(4-Fluorophenyl)-6-isopropyl-2-[[methyl(methylsulfonyl)amino]-5-[(tributylphosphonio)methyl]pyrimidine bromide; Tributyl(4-(4-fluorophenyl)-6-isopropyl-2-((N-methylmethylsulfonamido)pyrimidin-5-yl)methyl)phosphonium bromide; Phosphonium, tributyl[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[[methyl(methylsulfonyl)amino]pyrimidin-5-yl]methyl]-, bromide; CAS 853066-73-6; Sulfonylamino Pyrimidine Phosphonium Salt; Fluorophenyl Isopropyl Pyrimidine Phosphine Bromide Derivative
EINECS	Contact for details

Quality Control

Our production of Tributyl[4-(4-Fluorophenyl)-6-Isopropyl-2-[(2-n-Methyl-n-Methyl Sulfonyl)Amino]Pyrimidine-5-Yl-Methyl]Phosphine Bromine adheres to stringent quality protocols suitable for research and development applications. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing key parameters such as assay (HPLC), related substances, and residual solvents are available upon request. We support compliance with cGMP standards where required for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.