Description

Ethyl 3-(1,2-Dimethyl-1H-Indol-3-Yl)-4,4,4-Trifluoro-3-Hydroxybutanoate is a high-value, multifunctional synthetic intermediate characterized by its unique indole and trifluoromethyl hydroxybutanoate structure. This compound matters for its role as a critical building block in the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides, leveraging the biological activity of the indole moiety.
• Fluorinated Compound Synthesis: Serves as a versatile scaffold for introducing the trifluoromethyl group into target molecules, a common strategy to enhance metabolic stability and lipophilicity.
• Fine Chemical Production: Employed in the manufacture of complex dyes, pigments, and other performance chemicals where the indole structure is beneficial.
• Academic & Contract Research: Utilized in university and CRO laboratories for methodological studies in organic synthesis and medicinal chemistry.

Basic Information

Product Name	Ethyl 3-(1,2-Dimethyl-1H-Indol-3-Yl)-4,4,4-Trifluoro-3-Hydroxybutanoate
CAS No.	852991-34-5
Molecular Formula	C₁₆H₁₈F₃NO₃
Molecular Weight	329.32 g/mol
Synonyms	Ethyl 4,4,4-trifluoro-3-hydroxy-3-(1,2-dimethyl-1H-indol-3-yl)butanoate; 3-(1,2-Dimethylindol-3-yl)-4,4,4-trifluoro-3-hydroxybutyric Acid Ethyl Ester; 852991-34-5; Butanoic acid, 3-(1,2-dimethyl-1H-indol-3-yl)-4,4,4-trifluoro-3-hydroxy-, ethyl ester; TFHIBE; Ethyl 3-hydroxy-3-(1,2-dimethylindol-3-yl)-4,4,4-trifluorobutanoate
EINECS	Contact for details

Quality Control

Our Ethyl 3-(1,2-Dimethyl-1H-Indol-3-Yl)-4,4,4-Trifluoro-3-Hydroxybutanoate is produced under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation by atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.