Description

Ethyl 1-(tert-Butyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its pyrazole core and trifluoromethyl group. This compound matters for its critical role as a versatile building block in the synthesis of active pharmaceutical ingredients (APIs) and agrochemicals, where it imparts desirable metabolic stability and bioavailability. Industrial researchers and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors need this precise intermediate to develop new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel drug candidates, particularly in oncology, anti-inflammatory, and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Serves as a crucial precursor in the manufacture of modern pesticides and herbicides, leveraging the trifluoromethyl group for enhanced efficacy and environmental profile.
• Chemical Research & Development: Used in academic and industrial R&D labs for exploring new chemical entities and reaction pathways in heterocyclic chemistry.
• Material Science Precursor: Potential application in the synthesis of specialty polymers and functional materials requiring specific fluorinated heterocyclic structures.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects under cGMP conditions.

Basic Information

Product Name	Ethyl 1-(tert-Butyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate
CAS No.	852691-03-3
Molecular Formula	C11H15F3N2O2
Molecular Weight	264.25 g/mol
Synonyms	Ethyl 1-tert-butyl-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate; 1-(1,1-Dimethylethyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 1-tert-Butyl-5-trifluoromethyl-1H-pyrazole-4-carboxylic Acid Ethyl Ester; 852691-03-3; 1H-Pyrazole-4-carboxylic acid, 1-(1,1-dimethylethyl)-5-(trifluoromethyl)-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 1-(tert-Butyl)-5-(Trifluoromethyl)-1H-Pyrazole-4-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided with each shipment, detailing all relevant specifications. We support development and commercial projects requiring compliance with ICH guidelines and can supply material suitable for use in cGMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (typically 15-25°C). Keep away from incompatible materials such as strong oxidizing agents, strong acids, and strong bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.