Description

Methyl 5-Bromo-3-(2,2,2-Trifluoroacetamido)Thiophene is a high-purity, advanced pharmaceutical intermediate characterized by its brominated thiophene core and trifluoroacetamide protecting group. This compound matters for its critical role in the synthesis of complex bioactive molecules, particularly in medicinal chemistry and drug discovery programs. It is primarily needed by research institutions and pharmaceutical manufacturers developing novel therapeutics, where it serves as a key building block for creating targeted active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes due to its modifiable functional groups.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced crop protection agents and pesticides.
• Material Science: Potential building block for functionalized polymers and advanced organic electronic materials.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and GMP production.

Basic Information

Product Name	Methyl 5-Bromo-3-(2,2,2-Trifluoroacetamido)Thiophene
CAS No.	852330-31-5
Molecular Formula	C7H5BrF3NO2S
Molecular Weight	304.09 g/mol
Synonyms	5-Bromo-3-[(trifluoroacetyl)amino]-2-thiophenecarboxylic acid methyl ester; Methyl 5-bromo-3-[(trifluoroacetyl)amino]thiophene-2-carboxylate; 2-Thiophenecarboxylic acid, 5-bromo-3-[(trifluoroacetyl)amino]-, methyl ester; 852330-31-5; 5-Bromo-3-trifluoroacetamidothiophene-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our Methyl 5-Bromo-3-(2,2,2-Trifluoroacetamido)Thiophene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to quality supports compliance in regulated research and development environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.