Description

5-Bromo-3-(Chloromethyl)-1-Benzothiophene is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring both bromo and chloromethyl substituents on the benzothiophene core, makes it a versatile precursor for constructing complex molecules through sequential cross-coupling and substitution reactions. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of novel drug candidates, particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the preparation of advanced fungicides, herbicides, and plant growth regulators that require the benzothiophene scaffold.
• Material Science Precursor: Acts as a building block for organic semiconductors, liquid crystals, and other functional materials due to its electron-rich thiophene ring.
• Cross-Coupling Reactions: The bromine atom is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The reactive chloromethyl group allows for further functionalization with various nucleophiles, such as amines, alcohols, and thiols, to introduce diverse side chains.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules and probes for studying biological pathways and target engagement.

Basic Information

Product Name	5-Bromo-3-(Chloromethyl)-1-Benzothiophene
CAS No.	852180-53-1
Molecular Formula	C9H6BrClS
Molecular Weight	261.57 g/mol
Synonyms	5-Bromo-3-(chloromethyl)benzo[b]thiophene; 1-Benzothiophene, 5-bromo-3-(chloromethyl)-; 3-Chloromethyl-5-bromobenzothiophene; 5-Bromo-3-chloromethylbenzothiophene; Benzo[b]thiophene, 5-bromo-3-(chloromethyl)-
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-3-(Chloromethyl)-1-Benzothiophene is manufactured and tested under strict quality management protocols to ensure consistency and reliability for your critical research and production processes. Our products undergo rigorous quality testing, including HPLC, NMR, and GC-MS analysis, to ensure compliance with industry standards and your specific requirements. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.