Description

2-(tert-Butoxycarbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected amine (Boc) and a carboxylic acid functional group. This compound is critically important for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, such as protease inhibitors and other small-molecule drugs.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of active pharmaceutical ingredients (APIs), especially those targeting neurological and cardiovascular diseases.
• Medicinal Chemistry Research: Serves as a versatile scaffold for constructing compound libraries in drug discovery and lead optimization programs.
• Protease Inhibitor Development: Used in the research and production of inhibitors for various proteolytic enzymes, a significant class of therapeutic targets.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs (Contract Development and Manufacturing Organizations) for the cGMP production of novel drug candidates.
• Academic Research: Utilized in university and institutional labs for studying heterocyclic chemistry and developing new synthetic methodologies.

Basic Information

Product Name	2-(tert-Butoxycarbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid
CAS No.	851784-82-2
Molecular Formula	C15H17Cl2NO4
Molecular Weight	346.20 g/mol
Synonyms	Boc-5,7-Dichloro-Tic-OH; 6-Carboxy-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid tert-butyl ester; 5,7-Dichloro-2-[(2-methylpropan-2-yl)oxycarbonyl]-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; 2-Boc-5,7-dichloro-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; 5,7-Dichloro-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-6-carboxylic acid; 851784-82-2; tert-Butyl 5,7-dichloro-6-carboxy-3,4-dihydroisoquinoline-2(1H)-carboxylate
EINECS	Contact for details

Quality Control

Our 2-(tert-Butoxycarbonyl)-5,7-Dichloro-1,2,3,4-Tetrahydroisoquinoline-6-Carboxylic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports applications requiring high standards, including pre-clinical and clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.