Description

4-Difluoromethoxy-2-Methyl-Thiazole-5-Carboxylic Acid is a high-value, fluorinated heterocyclic building block essential for advanced organic synthesis. This compound matters as a critical intermediate in the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting new therapeutic agents. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key synthetic precursor for the development of novel drug candidates, especially in kinase inhibitor and antiviral research.
• Agrochemical Synthesis: Used in the research and production of advanced crop protection agents and herbicides.
• Material Science: Serves as a monomer or functional additive in the synthesis of specialty polymers and advanced materials.
• Chemical Research: A versatile building block for academic and industrial research in fluorinated heterocycle chemistry.
• Ligand and Catalyst Development: Utilized in the design of novel ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	4-Difluoromethoxy-2-Methyl-Thiazole-5-Carboxylic Acid
CAS No.	851755-45-8
Molecular Formula	C7H5F2NO3S
Molecular Weight	221.18 g/mol
Synonyms	2-Methyl-4-(difluoromethoxy)-1,3-thiazole-5-carboxylic acid; 4-(Difluoromethoxy)-2-methyl-5-thiazolecarboxylic acid; 5-Thiazolecarboxylic acid, 4-(difluoromethoxy)-2-methyl-; DFMTCA; 851755-45-8
EINECS	Contact for details

Quality Control

Our 4-Difluoromethoxy-2-Methyl-Thiazole-5-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.