Description

2-Chloro-1-[1-(Methylsulfonyl)-2,3-Dihydro-1H-Indol-5-Yl]Ethanone is a high-purity, advanced pharmaceutical intermediate characterized by its indole-based sulfonamide structure. This compound is of significant value for its role as a key building block in the synthesis of complex bioactive molecules, particularly in medicinal chemistry research and development. It is primarily sought after by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly those targeting neurological and oncological pathways.
• Medicinal Chemistry Research: Used as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Active Pharmaceutical Ingredient (API) Development: Serves as a key building block in the multi-step synthesis of complex APIs, especially those containing sulfonamide and indole moieties.
• Chemical Biology Probes: Utilized in the development of molecular probes for studying enzyme function and protein interactions within biological systems.
• Contract Research & Manufacturing (CRO/CMO): Supplied to service organizations supporting pharmaceutical companies with custom synthesis and process development.
• Academic Research: Employed in university and institutional labs for pioneering research in organic synthesis and new therapeutic methodologies.

Basic Information

Product Name	2-Chloro-1-[1-(Methylsulfonyl)-2,3-Dihydro-1H-Indol-5-Yl]Ethanone
CAS No.	851288-79-4
Molecular Formula	C11H10ClNO3S
Molecular Weight	271.72 g/mol
Synonyms	5-Acetyl-1-(methylsulfonyl)indoline-2-carbonyl chloride (common misnomer); 1-(1-Methylsulfonyl-2,3-dihydroindol-5-yl)-2-chloroethanone; 2-Chloro-1-(1-methylsulfonyl-2,3-dihydro-1H-indol-5-yl)ethan-1-one; 5-(2-Chloroacetyl)-1-(methylsulfonyl)indoline; CAS 851288-79-4; 1H-Indole-5-ethanone, 2-chloro-1-[1-(methylsulfonyl)-2,3-dihydro-]; 851288-79-4
EINECS	Contact for details

Quality Control

Our 2-Chloro-1-[1-(Methylsulfonyl)-2,3-Dihydro-1H-Indol-5-Yl]Ethanone is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity (typically ≥97% by HPLC), identity confirmation, and impurity profile is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and strong oxidizing agents. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single unknown impurity ≤ 1.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.