Description

Methyl 5-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-3-Carboxylate is a high-purity, advanced pharmaceutical intermediate characterized by its indazole core protected by a tetrahydropyran (THP) group. This compound is critical for medicinal chemistry research and development, serving as a versatile building block for the synthesis of novel bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on developing new therapeutic agents, particularly in oncology and CNS drug discovery.

Application

• Pharmaceutical Intermediate: A key precursor in the multi-step synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a scaffold for structure-activity relationship (SAR) studies and lead optimization in drug discovery programs.
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a potential linker or warhead component in the design of targeted protein degraders.
• Kinase Inhibitor Synthesis: The bromo-indazole structure is valuable for constructing potent and selective kinase inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs for the production of bespoke compounds for clinical trials.
• Academic Research: Employed in university and institutional labs for exploratory organic synthesis and chemical biology studies.

Basic Information

Product Name	Methyl 5-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-3-Carboxylate
CAS No.	850893-01-5
Molecular Formula	C14H15BrN2O3
Molecular Weight	339.19 g/mol
Synonyms	5-Bromo-1-(tetrahydro-2H-pyran-2-yl)-1H-indazole-3-carboxylic acid methyl ester; Methyl 5-bromo-1-(oxan-2-yl)-1H-indazole-3-carboxylate; 5-Bromo-1-THP-indazole-3-carboxylic acid methyl ester; 1-(Tetrahydro-2H-pyran-2-yl)-5-bromo-1H-indazole-3-carboxylic acid methyl ester; 850893-01-5; 5-Bromo-1-THP-1H-indazole-3-methyl carboxylate
EINECS	Contact for details

Quality Control

Our production of Methyl 5-Bromo-1-(Tetrahydro-2H-Pyran-2-Yl)-1H-Indazole-3-Carboxylate adheres to stringent quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, confirming compliance with customer specifications. Our quality commitment supports applications requiring high-purity intermediates for regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep the container sealed to protect from moisture. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.