Description

2-Boc-5-(2-Isopropylamino-Thiazol-4-Yl)-Isoindoline CAS NO 850877-62-2 is a high-purity, advanced pharmaceutical intermediate featuring a unique isoindoline core modified with a Boc-protected amine and a substituted thiazole moiety. This compound is of significant value in medicinal chemistry for its role as a versatile building block in the synthesis of complex, biologically active molecules. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of new therapeutic agents, particularly within oncology and central nervous system (CNS) drug discovery pipelines.

Application

• Pharmaceutical Intermediate: A critical precursor in the multi-step synthesis of novel drug candidates, especially those targeting protein-protein interactions.
• Protease Inhibitor Research: Used in the development of small-molecule inhibitors for various protease enzymes.
• Kinase Inhibitor Scaffold: Serves as a core structural element for designing and optimizing potent kinase inhibitors.
• Chemical Biology Probes: Employed in the creation of tool compounds for studying specific biological pathways and target validation.
• Peptidomimetic Development: The isoindoline-thiazole structure mimics peptide motifs, making it valuable for creating stable peptidomimetics.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom API synthesis projects.

Basic Information

Product Name	2-Boc-5-(2-Isopropylamino-Thiazol-4-Yl)-Isoindoline
CAS No.	850877-62-2
Molecular Formula	C20H26N4O2S
Molecular Weight	386.51 g/mol
Synonyms	tert-Butyl 5-(2-((propan-2-yl)amino)-1,3-thiazol-4-yl)-2,3-dihydro-1H-isoindole-2-carboxylate; 2-(tert-Butoxycarbonyl)-5-[2-(isopropylamino)-1,3-thiazol-4-yl]isoindoline; 5-(2-Isopropylaminothiazol-4-yl)isoindoline-2-carboxylic acid tert-butyl ester; Boc-isoindoline-thiazole intermediate; 850877-62-2
EINECS	Contact for details

Quality Control

Our 2-Boc-5-(2-Isopropylamino-Thiazol-4-Yl)-Isoindoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and mass spectrometry, to ensure it meets the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with complete chromatographic data are provided for every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.