Description

Morphinan-6-One, 17-(Cyclopropylmethyl)-4,5-Epoxy-3,14-Dihydroxy-, Hydrochloride, Hydrate (1:1:2), (5α)- is a high-purity pharmaceutical intermediate of significant importance in advanced medicinal chemistry research and development. This compound, supplied with CAS number 850808-02-5, is a key synthetic precursor in the production of specialized opioid receptor ligands and other bioactive molecules. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers focused on central nervous system (CNS) therapeutics.

Application

• Pharmaceutical Intermediate: Critical precursor in the synthesis of novel opioid analgesics and antagonist compounds for pain management research.
• Medicinal Chemistry Research: Used as a building block for structure-activity relationship (SAR) studies to develop new CNS-active agents with modified pharmacological profiles.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Employed in vitro studies to investigate interactions with opioid receptor subtypes (μ, κ, δ).
• Process Development: Used in scaling up and optimizing synthetic routes for the production of related active pharmaceutical ingredients (APIs).
• Academic Research: A key reagent for universities and institutes studying neuropharmacology and the biochemistry of addiction.

Basic Information

Product Name	Morphinan-6-One, 17-(Cyclopropylmethyl)-4,5-Epoxy-3,14-Dihydroxy-, Hydrochloride, Hydrate (1:1:2), (5α)-
CAS No.	850808-02-5
Molecular Formula	C22H27NO4 · HCl · 2H2O
Molecular Weight	435.92 g/mol (anhydrous free base: 369.46 g/mol)
Synonyms	17-Cyclopropylmethyl-4,5α-epoxy-3,14-dihydroxymorphinan-6-one hydrochloride dihydrate; Noroxymorphone cyclopropylmethyl derivative hydrochloride hydrate; 5α-Noroxymorphone-17-cyclopropylmethyl hydrochloride dihydrate; CP-45,634 hydrochloride dihydrate; (5α)-17-(Cyclopropylmethyl)-4,5-epoxymorphinan-3,6,14-triol hydrochloride dihydrate; 6-Oxymorphinol cyclopropylmethyl ether hydrochloride hydrate
EINECS	Contact for details

Quality Control

This product is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. While not intended for direct human use, our production adheres to principles of current Good Manufacturing Practice (cGMP) for intermediates to guarantee reliability and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and opened under controlled conditions to minimize exposure to atmospheric moisture and light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	7.0% - 9.5% (Theoretical for dihydrate: ~8.26%)
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single unknown impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.