Description

4-Benzyloxy-1-tert-Butoxycarbonylindole-2-Boronic Acid is a sophisticated indole-based boronic acid derivative, serving as a critical building block in modern synthetic organic chemistry. Its value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecular architectures. This high-purity intermediate is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of complex indole-based drug candidates, including kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in constructing novel heterocyclic compounds for crop protection agents and pesticides.
• Material Science Research: Building block for creating organic electronic materials, ligands for catalysts, and advanced polymers.
• Suzuki-Miyaura Cross-Coupling: Serves as the boronic acid coupling partner for introducing the functionalized indole moiety into biaryl and heterobiaryl systems.
• Chemical Biology & Probe Development: Utilized in synthesizing molecular probes and labeled compounds for biological target identification and validation.
• Academic & Process R&D: Enables route scouting and optimization for the scalable production of high-value fine chemicals.

Basic Information

Product Name	4-Benzyloxy-1-tert-Butoxycarbonylindole-2-Boronic Acid
CAS No.	850568-52-4
Molecular Formula	C20H22BNO5
Molecular Weight	367.21 g/mol
Synonyms	1-Boc-4-benzyloxyindole-2-boronic acid; 1-(tert-Butoxycarbonyl)-4-(benzyloxy)-1H-indole-2-boronic acid; 4-(Benzyloxy)-1-[(tert-butoxy)carbonyl]-1H-indole-2-boronic acid; 2-Borono-4-benzyloxy-1-tert-butoxycarbonylindole; 4-Benzyloxy-1-Boc-indole-2-boronic acid; BOC-4-OBn-Indole-2-Boronic Acid; 850568-52-4
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-1-tert-Butoxycarbonylindole-2-Boronic Acid is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and development applications. Each lot is characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (argon/nitrogen) when possible to maintain stability. Keep container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95% (Area %)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.