Description

1-Boc-6-Methylindole-2-Boronic Acid is a high-purity, advanced pharmaceutical intermediate featuring a protected indole core and a boronic acid functional group. This compound is critical for facilitating efficient cross-coupling reactions, such as the Suzuki-Miyaura reaction, which are foundational to modern medicinal chemistry and drug discovery. It is primarily utilized by research scientists and process chemists in the pharmaceutical and agrochemical industries for the synthesis of complex, biologically active molecules targeting a range of therapeutic areas.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those containing complex indole-based structures.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the formation of carbon-carbon bonds to attach diverse aryl or heteroaryl groups to the indole scaffold under mild conditions.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and improve compound efficacy.
• Agrochemical Synthesis: Serves as a precursor in the development of new active ingredients for crop protection products.
• Chemical Biology Probes: Utilized in the creation of molecular probes for studying biological pathways and target engagement.
• Material Science Research: Potential precursor for the synthesis of organic electronic materials and functional polymers.

Basic Information

Product Name	1-Boc-6-Methylindole-2-Boronic Acid
CAS No.	850568-51-3
Molecular Formula	C₁₄H₁₈BNO₄
Molecular Weight	275.11 g/mol
Synonyms	1-Boc-6-Methyl-1H-indole-2-boronic acid; 2-Borono-6-methyl-1H-indole-1-carboxylic acid 1,1-dimethylethyl ester; tert-Butyl 6-methyl-2-borono-1H-indole-1-carboxylate; 6-Methyl-1-[(2-methyl-2-propanyl)oxycarbonyl]-1H-indole-2-boronic acid; 1-Boc-6-methylindole-2-BA; BOC-6-Methylindole-2-boronic acid; 1-(tert-Butoxycarbonyl)-6-methyl-1H-indole-2-boronic acid
EINECS	Contact for details

Quality Control

Our 1-Boc-6-Methylindole-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and batch-to-batch consistency for your critical research and development processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and light-sensitive nature. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.