Description

1H-Indazole-1,3-Dicarboxylic Acid, 5-Iodo-, 1-(1,1-Dimethylethyl) 3-Methyl Ester is a high-purity, multi-functional chemical building block designed for advanced organic synthesis. Its core value lies in its unique indazole core structure, which is iodinated at the 5-position and protected with tert-butyl and methyl ester groups, making it an essential intermediate for constructing complex heterocyclic molecules. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel drug candidates, particularly those targeting kinase inhibition and other enzyme-related pathways.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the bioactivity of the iodinated indazole scaffold.
• Material Science: Acts as a building block for creating specialized polymers and organic electronic materials with unique optoelectronic properties.
• Chemical Biology: Employed in the design and synthesis of molecular probes and tags for studying biological processes and protein interactions.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	1H-Indazole-1,3-Dicarboxylic Acid, 5-Iodo-, 1-(1,1-Dimethylethyl) 3-Methyl Ester
CAS No.	850363-55-2
Molecular Formula	C15H17IN2O4
Molecular Weight	416.21 g/mol
Synonyms	5-Iodo-1H-indazole-1,3-dicarboxylic acid 1-tert-butyl 3-methyl ester; 1-(tert-Butyl) 3-methyl 5-iodo-1H-indazole-1,3-dicarboxylate; tert-Butyl methyl 5-iodo-1H-indazole-1,3-dicarboxylate; 5-Iodo-1H-indazole-1,3-dicarboxylic acid 1-tert-butyl ester 3-methyl ester; 850363-55-2; 1,3-Di-tert-butyl 5-iodo-1H-indazole-1,3-dicarboxylate (related compound); 5-Iodoindazole-1,3-dicarboxylic acid di-tert-butyl ester (related compound)
EINECS	Contact for details

Quality Control

Our production of 1H-Indazole-1,3-Dicarboxylic Acid, 5-Iodo-, 1-(1,1-Dimethylethyl) 3-Methyl Ester adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. All materials undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We operate under a quality system that supports cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediates, ensuring traceability and documentation for regulatory compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong alkalis and incompatible organic solvents. Due to its light-sensitive nature, handling and packaging should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.