Description

6-(Methylsulfonyl)-1-(Oxiran-2-Ylmethoxy)-1H-Indole is a high-purity, advanced pharmaceutical intermediate featuring a unique indole core functionalized with both methylsulfonyl and epoxide-containing side chains. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel, targeted therapeutic agents. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of small-molecule drugs, particularly for oncology and inflammatory diseases.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel active pharmaceutical ingredients (APIs) targeting specific biological pathways.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to develop new drug candidates with improved efficacy and selectivity.
• Kinase Inhibitor Development: The functional groups present make it a valuable scaffold for creating potent and selective kinase inhibitors, a major class of oncology drugs.
• Chemical Biology Probes: Employed in the design of molecular probes to study enzyme function and cellular signaling mechanisms.
• Custom Synthesis: Utilized by contract research and manufacturing organizations (CROs/CMOs) for bespoke synthesis projects under cGMP or research-grade conditions.

Basic Information

Product Name	6-(Methylsulfonyl)-1-(Oxiran-2-Ylmethoxy)-1H-Indole
CAS No.	849924-91-0
Molecular Formula	C₁₄H₁₅NO₅S
Molecular Weight	309.34 g/mol
Synonyms	1-(Oxiran-2-ylmethoxy)-6-(methylsulfonyl)-1H-indole; 6-Methanesulfonyl-1-(oxiran-2-ylmethoxy)indole; 1H-Indole, 6-(methylsulfonyl)-1-(oxiran-2-ylmethoxy)-; Glycidyl 6-(Methylsulfonyl)-1H-indol-1-yl Ether; Epoxide-functionalized indole derivative
EINECS	Contact for details

Quality Control

Our 6-(Methylsulfonyl)-1-(Oxiran-2-Ylmethoxy)-1H-Indole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles as determined by advanced analytical techniques like HPLC, NMR, and MS. We support development and commercial projects with material suitable for research use or produced under current Good Manufacturing Practice (cGMP) guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be moisture-sensitive; keep the container tightly sealed under an inert atmosphere if necessary. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.