Description

Ethyl 2-Amino-4-(3-Fluorophenyl)Thiophene-3-Carboxylate is a high-purity, fluorinated thiophene derivative serving as a critical building block in advanced organic synthesis. This compound matters for its role as a versatile intermediate in the development of novel pharmaceuticals and agrochemicals, where its unique molecular scaffold enables the creation of compounds with targeted biological activity. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for constructing complex heterocyclic systems.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides, leveraging the bioactivity of the thiophene core.
• Material Science: Serves as a monomer or functional additive in the research of conductive polymers and organic semiconductors.
• Chemical Synthesis: A versatile building block for constructing complex heterocyclic compounds in medicinal and combinatorial chemistry.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and novel compound library generation.

Basic Information

Product Name	Ethyl 2-Amino-4-(3-Fluorophenyl)Thiophene-3-Carboxylate
CAS No.	849659-38-7
Molecular Formula	C13H12FNO2S
Molecular Weight	265.30 g/mol
Synonyms	Ethyl 2-Amino-4-(3-fluorophenyl)thiophene-3-carboxylate; 2-Amino-4-(3-fluorophenyl)thiophene-3-carboxylic acid ethyl ester; 3-Thiophenecarboxylic acid, 2-amino-4-(3-fluorophenyl)-, ethyl ester; Ethyl α-amino-4-(m-fluorophenyl)thiophene-3-carboxylate; 849659-38-7; AKOS005258555; ZINC3848261
EINECS	Contact for details

Quality Control

Our Ethyl 2-Amino-4-(3-Fluorophenyl)Thiophene-3-Carboxylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and structural identity. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, supporting compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.