Description

1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-(Methylsulfonyl)- is a high-purity, advanced pharmaceutical intermediate belonging to the pyrrolopyridine class of heterocyclic compounds. This compound is a critical building block in modern medicinal chemistry, valued for its unique fused-ring structure that serves as a core scaffold in drug discovery programs. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly kinase inhibitors and other targeted small-molecule drugs.

Application

• Pharmaceutical Intermediate: A key synthetic precursor in the research and development of new active pharmaceutical ingredients (APIs), especially for oncology and anti-inflammatory targets.
• Kinase Inhibitor Synthesis: Serves as a privileged scaffold for constructing potent and selective kinase inhibitors due to its ability to mimic ATP and interact with kinase binding pockets.
• Medicinal Chemistry Research: Used extensively in structure-activity relationship (SAR) studies and lead optimization campaigns to improve drug potency, selectivity, and pharmacokinetic properties.
• Biochemical Probe Development: Employed in the creation of chemical probes for studying specific biological pathways and target validation in cellular assays.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up services for preclinical and clinical trial material.
• Academic Research: Used in university laboratories for fundamental research in organic synthesis methodology and heterocyclic chemistry.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-(Methylsulfonyl)-
CAS No.	849068-04-8
Molecular Formula	C8H7BrN2O2S
Molecular Weight	275.12 g/mol
Synonyms	5-Bromo-1-(methylsulfonyl)-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-methanesulfonyl-1H-pyrrolo[2,3-b]pyridine; 1H-Pyrrolo[2,3-b]pyridine, 5-bromo-1-(methylsulfonyl)-; 849068-04-8; 5-Bromo-1-(methylsulfonyl)-7-azaindole; 5-Bromo-1-mesyl-1H-pyrrolo[2,3-b]pyridine; 5-Bromo-1-(methylsulfonyl)-1H-pyrrolo[2,3-b]pyridine
EINECS	Contact for details

Quality Control

Our production of 1H-Pyrrolo[2,3-B]Pyridine, 5-Bromo-1-(Methylsulfonyl)- adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to quality supports compliance with the standards required for research and development under cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.