Description

Pyrrolidine, 2-[Bis(3,5-Dimethylphenyl)[(Trimethylsilyl)Oxy]Methyl]-, (2S)- is a high-value, chiral organosilicon compound featuring a pyrrolidine scaffold and a silyl-protected benzhydryl-like moiety. This advanced synthetic intermediate is critical for its role in facilitating stereoselective transformations, particularly in the synthesis of complex pharmaceutical molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for developing novel active pharmaceutical ingredients (APIs) and other high-purity specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral building block in the asymmetric synthesis of complex drug candidates, particularly those targeting central nervous system (CNS) disorders.
• Catalyst Ligand Precursor: Used in the development and synthesis of novel chiral ligands for asymmetric catalysis, such as in hydrogenation or cross-coupling reactions.
• Fine Chemical Synthesis: Employed in research-scale and pilot-scale syntheses of high-value, optically active compounds for agrochemicals and advanced materials.
• Academic & Industrial R&D: Serves as a critical reagent in methodological development for new synthetic routes requiring stereochemical control.
• Process Chemistry: Utilized in route scouting and optimization for the commercial-scale production of enantiomerically pure pharmaceuticals.

Basic Information

Product Name	Pyrrolidine, 2-[Bis(3,5-Dimethylphenyl)[(Trimethylsilyl)Oxy]Methyl]-, (2S)-
CAS No.	848821-60-3
Molecular Formula	C25H37NOSi
Molecular Weight	395.66 g/mol
Synonyms	(2S)-2-{[Bis(3,5-dimethylphenyl)(trimethylsilyloxy)methyl]pyrrolidine}; (S)-2-((Bis(3,5-dimethylphenyl)((trimethylsilyl)oxy)methyl)pyrrolidine; 2-[(Bis(3,5-dimethylphenyl)(trimethylsilyloxy)methyl]-(S)-pyrrolidine; (S)-2-[Bis(3,5-dimethylphenyl)(trimethylsiloxy)methyl]pyrrolidine; (S)-TMS-Protected Benzhydryl Pyrrolidine Derivative; Chiral Pyrrolidine Silyl Ether; 848821-60-3
EINECS	Contact for details

Quality Control

Every batch of Pyrrolidine, 2-[Bis(3,5-Dimethylphenyl)[(Trimethylsilyl)Oxy]Methyl]-, (2S)- is produced and controlled under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and enantiomeric purity, meeting the exacting standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when appropriate to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.