Description

1-Boc-2-(2'-Chloroacetyl)-Pyrrolidine is a high-purity, protected pyrrolidine derivative serving as a critical chiral building block in advanced organic synthesis. This compound matters for its role in constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and bioactive compounds. Pharmaceutical R&D teams, contract research organizations (CROs), and fine chemical manufacturers need it for synthesizing peptidomimetics, protease inhibitors, and other nitrogen-containing heterocycles with high stereochemical fidelity.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially protease inhibitors and kinase inhibitors.
• Peptidomimetic Synthesis: Used to introduce chiral, constrained pyrrolidine scaffolds into peptide backbones to enhance metabolic stability and bioavailability.
• Asymmetric Synthesis: Serves as a chiral auxiliary or building block for constructing stereocenters in complex natural products and fine chemicals.
• API Development: Integral in the research and process development stages for new Active Pharmaceutical Ingredients (APIs).
• Chemical Biology Probes: Utilized in the creation of specialized molecular probes for studying enzyme function and biological pathways.
• Custom Synthesis: A starting material for contract manufacturing organizations (CMOs) producing bespoke compounds for client projects.

Basic Information

Product Name	1-Boc-2-(2'-Chloroacetyl)-Pyrrolidine
CAS No.	848819-60-3
Molecular Formula	C11H18ClNO3
Molecular Weight	247.72 g/mol
Synonyms	1-(tert-Butoxycarbonyl)-2-(2-chloroacetyl)pyrrolidine; 2-(2-Chloroacetyl)-1-[(2-methylpropan-2-yl)oxycarbonyl]pyrrolidine; tert-Butyl 2-(2-chloroacetyl)pyrrolidine-1-carboxylate; N-Boc-2-(2-Chloroacetyl)pyrrolidine; 1-Boc-2-(2-Chloroacetyl)pyrrolidine; Pyrrolidine-1-carboxylic acid, 2-(2-chloroacetyl)-, 1,1-dimethylethyl ester; 848819-60-3; N-Boc-2-(chloroacetyl)pyrrolidine
EINECS	Contact for details

Quality Control

Our 1-Boc-2-(2'-Chloroacetyl)-Pyrrolidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure compliance with exacting standards for pharmaceutical R&D. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to prevent moisture absorption. Handle and store in accordance with good laboratory practices.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.